Primary Cilia Deficiency Induces Intracranial Aneurysm
نویسندگان
چکیده
منابع مشابه
Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm.
BACKGROUND Intracranial aneurysm (IA) is a common vascular disorder that frequently leads to fatal vascular rupture. Although various acquired risk factors associated with IA have been identified, the hereditary basis of IA remains poorly understood. As a result, genetically modified animals accurately modeling IA and related pathogenesis have been lacking, and subsequent drug development has b...
متن کاملDeficiency of Endothelial-Specific Transcription Factor Sox17 Induces Intracranial Aneurysm
re rea a a t t t t Abstract Background—Intracranial aneurysm (IA) is a common vascular disorder, which frequently leads
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Background and Aim: This study aimed to present the results of early and delayed operation on patients with ruptured brain aneurysms. In addition to comparing the results and rates of morbidity and mortality in the surgical procedure and identifying the effective factors, this study aimed to provide methods to improve the treatment of brain aneurysm. Methods and Materials/Patients: This was a ...
متن کاملPrimary cilia
The primary cilium was first so named by Sergei Sorokin in 1968.[1] Since the discovery of primary cilium in 1898 by Zimmerman, three major hypotheses for their function have been put forth. The first is that primary cilia are vestigial organelles inherited from an ancestor whose cells had motile cilia and now are of no purpose in multicellular organisms. The second is that they are involved in...
متن کاملGiant intracranial aneurysm.
E604 CMAJ, June 14, 2011, 183(9) © 2011 Canadian Medical Association or its licensors A45-year-old man was brought to the emergency department by his family because of a change in personality and inappropriate behaviour that had progressed over several years. In the weeks before admission, he had become increasingly agitated, confused and lethargic. On examination, he was drowsy and displayed f...
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ژورنال
عنوان ژورنال: Shock
سال: 2018
ISSN: 1073-2322,1540-0514
DOI: 10.1097/shk.0000000000000961